Which closure device relies on extravascular collagen to seal the arteriotomy?

• A. Mynx closure device
• B. Duett closure device
• C. Angioseal closure device
• D. Starclose closure device

Answer: (A)

The mechanism being tested is sealing the arteriotomy with an extravascular collagen plug. Angioseal uses an intravascular anchor inside the artery plus an external collagen plug that sits on the puncture site outside the vessel. The external collagen plug compresses the arteriotomy and provides a scaffold for clot formation, achieving hemostasis from the outside while the internal anchor helps maintain closure from within.

Mynx, in contrast, relies on a polymer hydrogel sealant placed externally to seal the puncture, not collagen. The other devices achieve closure via clips or sutures rather than an extravascular collagen plug. So the device that relies on extravascular collagen to seal the arteriotomy is Angioseal.